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Article

Host-Derived Lactic Acid Disrupts IFN Clinical Efficacy via Antiviral Inhibition and Proinflammatory Amplification

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>Emergent, sudden-onset, and highly prevalent viral pathogens severely threaten public health. Current vaccines/antiviral drugs are limited by narrow tropism, susceptibility to escape mutations, and prolonged development, highlighting an urgent need for broad-spectrum agents. Type I interferons exhibit potent broad-spectrum antiviral activity in preclinical studies but suffer from critic...

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Literature Corpus work
b0e3a852-3da2-58d6-9e70-cf981f539c2f
DOI
10.21203/rs.3.rs-8905265/v1
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Host-Derived Lactic Acid Disrupts IFN Clinical Efficacy via Antiviral Inhibition and Proinflammatory AmplificationDOI 10.21203/rs.3.rs-8905265/v1
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