Article

Beyond Metabolism: Pyruvate Carboxylase Acts as a Sequence-Selective Small RNA Sensor Orchestrating Antiviral Responses

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Interleukin-27 (IL-27) is an anti-HIV cytokine that induces 14 novel microRNAs (miRNAs) in primary CD4(+) T cells. We previously reported that transfection of two of these miRNA mimics, miRTC10 and miRTC14 into human primary macrophages, differentially induced interferon (IFN)-α2, -α8, -α13, and -λ1 expression. However, the mechanism underlying this activation remains unclear. Here, we demonstra...

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Literature Corpus work: 6673966d-0e02-5881-b279-1ab99d696720
DOI: 10.64898/2026.06.29.735367

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