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Article

HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection

13 Sept 2018

Abstract excerpt

Human noroviruses are a leading cause of gastroenteritis throughout the world but are challenging to study in vivo and in vitro . Murine norovirus (MNoV) provides a tractable genetic and small-animal model to study norovirus biology and immune responses. Interferons are critical mediators of antiviral immunity, but excessive expression can dysregulate the immune system. IFN-λ plays an important role at mucosal...

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PMID: 30209176
DOI: 10.1128/jvi.01368-18

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