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Metabolic deficiencies underlie reduced plasmacytoid dendritic cell IFN-I production following viral infection

7 Feb 2025

Abstract excerpt

Type I Interferons (IFN-I) are central to host protection against viral infections, with plasmacytoid dendritic cells (pDC) being the most significant source, yet pDCs lose their IFN-I production capacity following an initial burst of IFN-I, resulting in susceptibility to secondary infections. The underlying mechanisms of these dynamics are not well understood. Here we find that viral infection reduces the...

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PMID: 39920132
DOI: 10.1038/s41467-025-56603-5

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