Article

Amyloid precursor protein causes fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load

2020-09-21

Abstract excerpt

<h4>Background: </h4> The amyloid precursor protein (APP) is a type I transmembrane protein with unknown physiological function. Amyloidogenic processing of APP causes the generation of different cleavage products amongst b-amyloid and the APP C-terminal (APP-CT) fragment.METHODS1D, cerebral organoid 3D cell culture and human hippocampal post-mortem tissue were used to study APP-CT signalling in combination with i...

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Literature Corpus work: b0e28826-5dda-556e-b8b5-74c60db2a562
DOI: 10.21203/rs.3.rs-74943/v1

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