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Article

Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death.

Molecular biology of the cell - 1 May 2011

Chang Kuei-Hua, Multani Parminder Singh, Sun Kai-Hui, Vincent Fabien, de Pablo Yolanda, Ghosh Soumitra, Gupta Ritika, Lee Hyun-Pil, Lee Hyoung-Gon, Smith Mark A, Shah Kavita

Abstract excerpt

Nuclear fragmentation is a common feature in many neurodegenerative diseases, including Alzheimer's disease (AD). In this study, we show that nuclear lamina dispersion is an early and irreversible trigger for cell death initiated by deregulated Cdk5, rather than a consequence of apoptosis. Cyclin-dependent kinase 5 (Cdk5) activity is significantly increased in AD and contributes to all three hallmarks: neurotoxic...

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Identifiers

PMID: 21389115
DOI: 10.1091/mbc.E10-07-0654
PMCID: PMC3084668

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