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Article

Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia

15 Jul 2023

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The critical genetic players of ALS and FTD are the TARDBP, FUS and C9orf72 genes, whose protein products, TDP-43, FUS and the C9orf72-dipeptide repeat proteins, accumulate in form of cytoplasmic inclusions. The majority of the studies focus on the...

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PMID: 37454169
DOI: 10.1038/s41420-023-01547-2

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