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Engineered APP C-terminus Alters APP Expression Dynamics in Differentiated SH-SY5Y- Derived Neurons

2025-09-02

Abstract excerpt

<title>Abstract</title> <p>Alzheimer's disease (AD) pathology is deeply connected with the processing of amyloid precursor protein (APP) and its cleavage products. APP processing generates functional fragments, such as the APP intracellular domain (AICD) and the APP carboxy-terminal fragment (CTF), which have been thought to implicate transcriptional regulation; however, their potential role in modulating endogen...

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Literature Corpus work: b9db8568-46d7-54db-a9be-c354e51cdc26
DOI: 10.21203/rs.3.rs-7263985/v1

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