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Novel non hot spot modification in Fks1 of <i>Candida auris</i> confers echinocandin resistance

2023-04-03

Abstract excerpt

<h4>ABSTRACT</h4> We determined echinocandin susceptibility and FKS1 genotypes of thirteen clinical isolates of Candida auris recovered from four patients at a tertiary care center in Salvador, Brazil. Three isolates were categorized as echinocandin-resistant and harbored a novel FKS1 mutation leading to an amino acid change W691L located downstream from hot-spot 1. When introduced to echinocandin-susceptible...

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Literature Corpus work
b0d77ecc-334f-5cd0-8ed5-60210cd54d7e
DOI
10.1101/2023.03.29.534846
Open publication

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