Article
Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary-care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins.
Mycoses - 1 Mar 2022
Asadzadeh Mohammad, Mokaddas Eiman, Ahmad Suhail, Abdullah Aneesa A, de Groot Theun, Meis Jacques F, Shetty Shama A
Abstract excerpt
BACKGROUND: Candida auris is an emerging, potentially multidrug-resistant pathogen that exhibits clade-specific resistance to fluconazole and also develops resistance to echinocandins and amphotericin B easily. This study analysed 49 C auris isolates for alterations in hotspot-1 and hotspot-2 of FKS1 for the detection of mutations conferring reduced susceptibility to echinocandins. METHODS: C auris isolates...
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