Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.

Emerging microbes & infections - 1 Dec 2024

Tian Sufei, Wu Yusheng, Li Hailong, Rong Chen, Wu Na, Chu Yunzhuo, Jiang Ning, Zhang Jingping, Shang Hong

Abstract excerpt

INTRODUCTION: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations), remains poorly understood. Methods: Four clinical cases and 29 isolates associated with the incremental process of echinocandin resistance were collected and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal Agents
Share to Candidiasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Fungal

Share to Echinocandins

Share to Evolution, Molecular

Share to Fungal Proteins

Share to Glucosyltransferases

Share to Microbial Sensitivity Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 38989545
DOI: 10.1080/22221751.2024.2377584
PMCID: PMC11265302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.PMID 38989545Read ↗

Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary-care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins.Semantic proximity Read ↗

<i>FKS1/2</i> -variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory <i>Candida auris</i> infectionsSemantic proximity Read ↗

Genome-Wide Analysis of Experimentally Evolved Candida auris Reveals Multiple Novel Mechanisms of Multidrug Resistance.Semantic proximity Read ↗

Genome-wide analysis of experimentally evolved <i>Candida auris</i> reveals multiple novel mechanisms of multidrug-resistanceSemantic proximity Read ↗

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolatesSemantic proximity Read ↗

Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 SystemSemantic proximity Read ↗

Global Analysis of the Evolution and Mechanism of Echinocandin Resistance in Candida glabrataSemantic proximity Read ↗

Novel non hot spot modification in Fks1 of <i>Candida auris</i> confers echinocandin resistanceSemantic proximity Read ↗

<i>In vitro</i> evolution of caspofungin resistance in <i>Candidozyma auris</i> via <i>FKS1</i> hotspot I mutations results in moderate fitness trade-offs but no reduction in virulenceSemantic proximity Read ↗

Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance.Semantic proximity Read ↗

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.Semantic proximity Read ↗

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.