Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 System

29 Apr 2023

Abstract excerpt

Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of these mutations to echinocandin resistance remains unknown. Here, we sequenced the FKS1 gene of a caspofungin-resistant clinical isolate (clade I) and identified a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Nematode management and characterization studies
Share to Parasitic Diseases Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37233240
DOI: 10.3390/jof9050529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 SystemPMID 37233240Read ↗

Novel non hot spot modification in Fks1 of <i>Candida auris</i> confers echinocandin resistanceSemantic proximity Read ↗

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.Semantic proximity Read ↗

Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris.Semantic proximity Read ↗

Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrataSemantic proximity Read ↗

Candida parapsilosis isolates carrying mutations outside FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance.Semantic proximity Read ↗

Molecular characterisation of Candida auris isolates from immunocompromised patients in a tertiary-care hospital in Kuwait reveals a novel mutation in FKS1 conferring reduced susceptibility to echinocandins.Semantic proximity Read ↗

<i>In vitro</i> evolution of caspofungin resistance in <i>Candidozyma auris</i> via <i>FKS1</i> hotspot I mutations results in moderate fitness trade-offs but no reduction in virulenceSemantic proximity Read ↗

Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection.Semantic proximity Read ↗

A <i>Candidozyma (Candida) auris</i> -optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding <i>FKS1</i> mutationSemantic proximity Read ↗

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.Semantic proximity Read ↗

Genetic and Phenotypic Intra-Clade Variation in Candida auris Isolated from Critically Ill Patients in a New York City Tertiary Care Center.Semantic proximity Read ↗

Hotspot gene conversion between FKS1 and FKS2 in echinocandin resistant Candida glabrata serial isolatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.