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<i>In vitro</i> evolution of caspofungin resistance in <i>Candidozyma auris</i> via <i>FKS1</i> hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

2025-01-04

Abstract excerpt

Resistance to echinocandins in the recently emerged pathogen Candidozyma auris (previously known as Candida auris ) poses significant clinical challenges. This study reports the in vitro evolution of a caspofungin-sensitive C. auris clade II isolate to acquire caspofungin resistance. We sequenced the whole genome of the parental strain and its drug-resistant progeny. The resistant isolates harboured mutations...

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Literature Corpus work
3c5d5c79-b21f-522f-b1c6-079d19c30893
DOI
10.1101/2024.12.18.629118
Open publication

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<i>In vitro</i> evolution of caspofungin resistance in <i>Candidozyma auris</i> via <i>FKS1</i> hotspot I mutations results in moderate fitness trade-offs but no reduction in virulenceDOI 10.1101/2024.12.18.629118
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