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Article

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.

Antimicrobial agents and chemotherapy - 18 Apr 2023

Hirayama Tatsuro, Miyazaki Taiga, Sumiyoshi Makoto, Ito Yuya, Ashizawa Nobuyuki, Takeda Kazuaki, Iwanaga Naoki, Takazono Takahiro, Yamamoto Kazuko, Izumikawa Koichi, Yanagihara Katsunori, Makimura Koichi, Tsukamoto Kazuhiro, Kohno Shigeru, Mukae Hiroshi

Abstract excerpt

Candida auris is resistant to multiple antifungal agents. This study investigated its antifungal susceptibility and explored FKS1 mutations across the isolates from mice enterically colonized with wild-type C. auris and treated with echinocandin. Resistant C. auris with FKS1 mutations, including S639F, S639Y, D642Y, R1354H, or R1354Y, were isolated and found to be micafungin- and caspofungin-resistant in vivo;...

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Identifiers

PMID: 36920237
DOI: 10.1128/aac.01243-22
PMCID: PMC10112215

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Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.PMID 36920237Read ↗

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