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A <i>Candidozyma (Candida) auris</i> -optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding <i>FKS1</i> mutation

2025-02-15

Abstract excerpt

<h4>Objectives: </h4> : Mutations in the Candidozyma (Candida) auris β-glucan synthase gene (FKS1) altering S639 are frequently associated with clinical echinocandin resistance. However, the direct impact of these mutations remains uncharacterized. We have developed a novel C. auris -optimized Episomal Plasmid-Induced Cas9 (EPIC) gene-editing system capable of recyclable precision genome editing and demonstrate...

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Literature Corpus work
51f14bc5-c8a4-56ba-9729-7cc6fff95bce
DOI
10.1101/2025.02.14.638356
Open publication

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A <i>Candidozyma (Candida) auris</i> -optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding <i>FKS1</i> mutationDOI 10.1101/2025.02.14.638356
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