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Caspofungin resistance in <i>Candia auris</i> due to mutations in <i>Fks</i> 1 with adjunctive role of chitin and key cell wall stress response pathway genes

2020-07-10

Abstract excerpt

The emergence of echinocandin resistance in C. auris has become a major concern. Point mutations in Fks1 subunit of β-D-glucan synthase is the primary mechanism in echinocandin resistance. However, resistant isolates with wild type Fks 1 are not infrequent. We screened 199 clinical C. auris isolates from 30 centres across India for echinocandin resistance. The cohort also contained six sequential isolates from...

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Literature Corpus work
c551edb6-175a-5160-8eeb-03e8a1853a10
DOI
10.1101/2020.07.09.196600
Open publication

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Caspofungin resistance in <i>Candia auris</i> due to mutations in <i>Fks</i> 1 with adjunctive role of chitin and key cell wall stress response pathway genesDOI 10.1101/2020.07.09.196600
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