Article

The evolution of genetic variability at the LRRK2 locus

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Leucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson’s disease (PD) accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage from infection in animal models. Here we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define...

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Literature Corpus work: b0b10a84-02a4-586d-9309-69f144c33a3b
DOI: 10.21203/rs.3.rs-4001026/v1

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