Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Evolution of Genetic Variability at the LRRK2 Locus.

Genes - 3 Jul 2024

Guenther Dylan T, Follett Jordan, Amouri Rim, Sassi Samia Ben, Hentati Faycel, Farrer Matthew J

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) c.6055G>A (p.G2019S) is a frequent cause of Parkinson's disease (PD), accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage against infection in animal models. Here, we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define the age of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alleles
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Haplotypes

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Parkinson Disease

Share to Selection, Genetic

Share to Tunisia

Source

Open in PubMed Open full text

Identifiers

PMID: 39062657
DOI: 10.3390/genes15070878
PMCID: PMC11275506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Evolution of Genetic Variability at the LRRK2 Locus.PMID 39062657Read ↗

The evolution of genetic variability at the LRRK2 locusSemantic proximity Read ↗

A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease.Semantic proximity Read ↗

The age at onset of LRRK2 p.Gly2019Ser Parkinson’s disease across ancestries and countries of originSemantic proximity Read ↗

The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.Semantic proximity Read ↗

LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.Semantic proximity Read ↗

Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.Semantic proximity Read ↗

Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.Semantic proximity Read ↗

LRRK2 Haplotype Analyses in European and North African Families with Parkinson Disease: A Common Founder for the G2019S Mutation Dating from the 13th CenturySemantic proximity Read ↗

Evidence for prehistoric origins of the G2019S mutation in the North African Berber population.Semantic proximity Read ↗

<i>LRRK2</i> parkinsonism in Tunisia and Norway: A comparative analysis of disease penetranceSemantic proximity Read ↗

Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans.Semantic proximity Read ↗

Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.