Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.

doi:10.1002/mds.23283

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Article

Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.

Movement disorders : official journal of the Movement Disorder Society - 15 Oct 2010

Jasinska-Myga Barbara, Kachergus Jennifer, Vilariño-Güell Carles, Wider Christian, Soto-Ortolaza Alexandra I, Kefi Mounir, Middleton Lefkos T, Ishihara-Paul Lianna, Gibson Rachel A, Amouri Rim, Yahmed Samia Ben, Sassi Samia Ben, Zouari Mourad, El Euch Ghada, Ross Owen A, Hentati Faycal, Farrer Matthew J

Abstract excerpt

The LRRK2 gene is a key player in Parkinson's disease (PD), however prevalence and pathogenicity of LRRK2 variants remain to be investigated in ethnically diverse populations. Herein, we performed comprehensive sequencing of the LRRK2 gene in 92 Tunisian probands with familial PD. We then perform...

Topics

Adult
Africa, Northern
Aged
Aged, 80 and over
Exons
Family Health
Female
Genotype
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation, Missense

Parkinsonian Disorders

Polymorphism, Single Nucleotide

Protein Serine-Threonine Kinases

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 20721913
DOI: 10.1002/mds.23283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-20721913-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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