Article
Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.
Movement disorders : official journal of the Movement Disorder Society - 15 Oct 2010
Jasinska-Myga Barbara, Kachergus Jennifer, Vilariño-Güell Carles, Wider Christian, Soto-Ortolaza Alexandra I, Kefi Mounir, Middleton Lefkos T, Ishihara-Paul Lianna, Gibson Rachel A, Amouri Rim, Yahmed Samia Ben, Sassi Samia Ben, Zouari Mourad, El Euch Ghada, Ross Owen A, Hentati Faycal, Farrer Matthew J
Abstract excerpt
The LRRK2 gene is a key player in Parkinson's disease (PD), however prevalence and pathogenicity of LRRK2 variants remain to be investigated in ethnically diverse populations. Herein, we performed comprehensive sequencing of the LRRK2 gene in 92 Tunisian probands with familial PD. We then performed an association study using all identified variants in a series of 167 Lrrk2 p.G2019S-negative patients with sporadic...
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