Article
Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families.
Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2007
Ishihara Lianna, Gibson Rachel A, Warren Liling, Amouri Rim, Lyons Kelly, Wielinski Catherine, Hunter Christine, Swartz Jina E, Elango Ramu, Akkari P Anthony, Leppert David, Surh Linda, Reeves Kevin H, Thomas Siwan, Ragone Leigh, Hattori Nobutaka, Pahwa Rajesh, Jankovic Joseph, Nance Martha, Freeman Alan, Gouider-Khouja Neziha, Kefi Mounir, Zouari Mourad, Ben Sassi Samia, Ben Yahmed Samia, El Euch-Fayeche Ghada, Middleton Lefkos, Burn David J, Watts Ray L, Hentati Faycal
Abstract excerpt
Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G > A) in the kinase domain of this gene in United States...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cross-Cultural Comparison
- DNA Mutational Analysis
- Family Health
- Female
- Genetic Testing