Article
A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease.
Parkinsonism & related disorders - 1 Jan 2008
Warren L, Gibson R, Ishihara L, Elango R, Xue Z, Akkari A, Ragone L, Pahwa Rajesh, Jankovic Joseph, Nance Martha, Freeman Alan, Watts Ray L, Hentati F
Abstract excerpt
The Leucine-rich repeat kinase 2 (LRRK2) gene has been identified as a disease susceptibility gene for Parkinson's disease (PD), with G2019 (6055G>A) being the most frequent mutation. This mutation was present in 42% (38/91) of Tunisian families and 2% (1/39) of US families we have studied. A founding haplotype was identified in our data and it is shared by families from Tunisia, US, European and Middle Eastern...
Topics
- Adult
- Aged
- Europe
- Female
- Founder Effect
- Genotype
- Haplotypes
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged