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Article

<i>LRRK2</i> parkinsonism in Tunisia and Norway: A comparative analysis of disease penetrance

10 Jul 2014

Abstract excerpt

In recent years, the molecular etiology of parkinsonism has yielded to genetic analysis.1 Mutations in the gene leucine-rich repeat kinase 2 ( LRRK2 ) have the highest genotypic and population attributable risk. Disparate penetrance estimates have been reported using a variety of statistical analyses, ethnic populations, and sample sizes.2 We compared the age-associated cumulative incidence (penetrance) of LRRK2...

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PMID: 25008396
DOI: 10.1212/wnl.0000000000000675

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