Article
Evidence for prehistoric origins of the G2019S mutation in the North African Berber population.
PloS one - 1 Jan 2017
Ben El Haj Rafiqua, Salmi Ayyoub, Regragui Wafa, Moussa Ahmed, Bouslam Naima, Tibar Houyam, Benomar Ali, Yahyaoui Mohamed, Bouhouche Ahmed
Abstract excerpt
The most common cause of the monogenic form of Parkinson's disease known so far is the G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2) gene. Its frequency varies greatly among ethnic groups and geographic regions ranging from less than 0.1% in Asia to 40% in North Africa. This mutation has three distinct haplotypes; haplotype 1 being the oldest and most common. Recent studies have dated haplotype 1 of...
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