Article
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.
Annals of neurology - 1 Jun 2026
Lüth Theresa, Laabs Björn-Hergen, Sendel Sebastian, König Inke R, Caliebe Amke, Noyce Alastair J, Screven Laurel A, Bardien Soraya, Farrer Matthew, Hentati Faycel, Amouri Rim, Klein Christine, Sassi Samia Ben, Trinh Joanne
Abstract excerpt
OBJECTIVES: The objective of this study was to elucidate differences in the cumulative incidence of Leucine-rich repeat kinase 2 (LRRK2) p.Gly2019Ser-related Parkinson's disease (PD; LRRK2-PD) between ancestries and countries. METHODS: We included 922 unrelated p.Gly2019Ser variant carriers (affected = 762 and unaffected = 160) from the Global Parkinson's Genetics Program (GP2) in addition to cohorts recruited...
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