Article

The age at onset of LRRK2 p.Gly2019Ser Parkinson’s disease across ancestries and countries of origin

2025-06-09

Abstract excerpt

<h4>Objectives</h4> The LRRK2 p.Gly2019Ser pathogenic variant has reduced penetrance and presents a wide range of age at onset (AAO) in patients with Parkinson’s disease (PD). We aim to elucidate differences in the cumulative incidence of LRRK2 p.Gly2019Ser - related PD ( LRRK2 -PD) between ancestries and countries. <h4>Methods</h4> We included N=922 unrelated LRRK2 p.Gly2019Ser variant carriers (affected: N=762,...

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Literature Corpus work: ee0f1de9-d838-528b-ab49-6db82cf47d34
DOI: 10.1101/2025.06.04.25327685

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