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Article

LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study.

The Lancet. Neurology - 1 Jul 2008

Hulihan Mary M, Ishihara-Paul Lianna, Kachergus Jennifer, Warren Liling, Amouri Rim, Elango Ramu, Prinjha Rab K, Upmanyu Ruchi, Kefi Mounir, Zouari Mourad, Sassi Samia Ben, Yahmed Samia Ben, El Euch-Fayeche Ghada, Matthews Paul M, Middleton Lefkos T, Gibson Rachel A, Hentati Fayçal, Farrer Matthew J

Abstract excerpt

BACKGROUND: Several genes have been implicated in the pathogenesis of Parkinson's disease (PD). The aim of this study was to define the clinical symptoms and age-associated cumulative incidence of the most frequent mutation associated with PD, LRRK2 Gly2019Ser. METHODS: 238 patients with sporadic PD and 371 unrelated control participants from the Arab-Berber population were screened at the Institut National de...

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PMID: 18539535
DOI: 10.1016/S1474-4422(08)70116-9

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