Article

DNA binding analysis of rare variants in homeodomains reveals novel homeodomain specificity-determining residues

2023-06-18

Abstract excerpt

<h4>Summary</h4> Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and play important roles in regulating development, body patterning, and cellular differentiation. Here, we analyzed 92 human HD mutants, including disease-associated variants and variants of unknown significance (VUSs), for their effects on DNA binding acti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7eba560a-606f-5afe-8ffd-b5ea2061cb00
DOI: 10.1101/2023.06.16.545320

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA binding analysis of rare variants in homeodomains reveals novel homeodomain specificity-determining residuesDOI 10.1101/2023.06.16.545320Read

DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.Semantic proximity Read

Codebook: sequence specificity and genomic binding of poorly-characterized human transcription factorsSemantic proximity Read

Survey of variation in human transcription factors reveals prevalent DNA binding changes.Semantic proximity Read

Missense variants in human forkhead transcription factors reveal determinants of forkhead DNA bispecificitySemantic proximity Read

Affinity-optimizing variants within the ZRS enhancer disrupt limb developmentSemantic proximity Read

Homeodomain revisited: a lesson from disease-causing mutations.Semantic proximity Read

NKX2-5 congenital heart disease mutations show diverse loss and gain of epigenomic, biochemical and chromatin search functions underpinning pathogenicitySemantic proximity Read

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factorsSemantic proximity Read

Intrinsic specificity differences between transcription factor paralogs partly explain their differential in vivo bindingSemantic proximity Read

In silico Analysis of CHD4 Mutations Reveals Domain-Specific Impacts on Cardiovascular Disorders Among Patients With Rare Diseases.Semantic proximity Read

The Genetics of Transcription Factor DNA Binding Variation.Semantic proximity Read

Evaluating the impact of single nucleotide variants on transcription factor binding.Semantic proximity Read