Article
DNA binding analysis of rare variants in homeodomains reveals homeodomain specificity-determining residues.
Nature communications - 10 Apr 2024
Kock Kian Hong, Kimes Patrick K, Gisselbrecht Stephen S, Inukai Sachi, Phanor Sabrina K, Anderson James T, Ramakrishnan Gayatri, Lipper Colin H, Song Dongyuan, Kurland Jesse V, Rogers Julia M, Jeong Raehoon, Blacklow Stephen C, Irizarry Rafael A, Bulyk Martha L
Abstract excerpt
Homeodomains (HDs) are the second largest class of DNA binding domains (DBDs) among eukaryotic sequence-specific transcription factors (TFs) and are the TF structural class with the largest number of disease-associated mutations in the Human Gene Mutation Database (HGMD). Despite numerous structural studies and large-scale analyses of HD DNA binding specificity, HD-DNA recognition is still not fully understood....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.