Article

Inducible alpha-synuclein overexpression affects human Neural Stem Cells behavior

2018-03-28

Abstract excerpt

Converging evidence suggest that levels of alpha-Synuclein (aSyn) expression play a critical role in Parkinson’s disease (PD). Several mutations of the SNCA gene, encoding for aSyn have been associated to either the familial or the sporadic forms of PD. Nonetheless, the mechanism underlying wild type aSyn-mediated neurotoxicity in neuronal cells as well as its specific driving role in PD pathogenesis has yet to be...

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Literature Corpus work: b02d443f-dc9b-514a-90eb-ccd0a4e0e621
DOI: 10.1101/290619

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