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Article

Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative Disease

9 Apr 2018

Abstract excerpt

) plays a central role in the pathogenesis of Parkinson's disease (PD) and related Lewy body disorders such as Parkinson's disease dementia, Lewy body dementia, and multiple system atrophy. Since its discovery as a disease-causing gene in 1997, alpha-synuclein has been a central point of scientific interest both at the protein and gene level. Mutations, including copy number variants, missense mutations, short...

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PMID: 29686602
DOI: 10.3389/fnins.2018.00199

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