Article

<i>Snca</i> -GFP knock-in mice reflect patterns of endogenous expression and pathological seeding

2020-05-05

Abstract excerpt

Alpha-synuclein (aSyn) participates in synaptic vesicle trafficking and synaptic transmission, but its misfolding is also strongly implicated in Parkinson’s disease (PD) and other neurodegenerative disorders known as synucleinopathies where misfolded aSyn accumulates in different regions of the central and peripheral nervous systems. Although increased aSyn expression levels or altered aggregation propensities lik...

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Literature Corpus work: 607c1f57-2227-5d3a-bc41-55d05c0ed739
DOI: 10.1101/2020.05.05.077321

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