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Article

Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease.

Stem cell research - 1 Mar 2017

Chumarina Margarita, Azevedo Carla, Bigarreau Julie, Vignon Clémentine, Kim Kwang-Soo, Li Jia-Yi, Roybon Laurent

Abstract excerpt

Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein (aSYN) mice expressing human mutant SNCAA53T under the control of the mouse Prion promoter (MoPrP), or wildtype (WT) mice. The expression of GFP and human aSYN was validated by...

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Source

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Identifiers

PMID: 28413000
DOI: 10.1016/j.scr.2016.12.026
PMCID: PMC5626016

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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