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Article

Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease

5 Mar 2008

Abstract excerpt

Alpha-synuclein (alpha-syn) has been implicated in the pathogenesis of many neurodegenerative disorders, including Parkinson's disease. These disorders are characterized by various neurological and psychiatric symptoms based on progressive neuropathological alterations. Whether the neurodegenerative process might be halted or even reversed is presently unknown. Therefore, conditional mouse models are powerful...

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PMID: 18322092
DOI: 10.1523/jneurosci.3040-07.2008

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