Article

Youth-associated protein TIMP2 alters microglial state and function in the context of aging

2025-05-21

Abstract excerpt

There is little understanding of how aging serves as the strongest risk factor for several neurogenerative diseases. Specific neural cell types, such as microglia, undergo age-related maladaptive changes, including increased inflammation, impaired debris clearance, and cellular senescence, yet specific mediators that regulate these processes remain unclear. The aged brain is rejuvenated by youth-associated plasma...

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Identifiers and source

Literature Corpus work: b021ac12-174b-5e65-aff9-d729b2baf638
DOI: 10.1101/2025.05.20.655226

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