Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance

Abstract excerpt

Several studies have identified blood proteins that influence brain aging performance in mice, yet translating these findings to humans remains challenging. Here we found that higher predicted plasma levels of Tissue Inhibitor of Metalloproteinases 2 (TIMP2) were significantly associated with improved global cognition and memory performance in humans. We first identified 12 proteins with aging or rejuvenating effe...

Topics

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• Bone Marrow
• Cognitive Dysfunction
• Genetic Predisposition to Disease
• Genetics, Aging, and Longevity in Model Organisms
• Genome-Wide Association Study
• Multifactorial Inheritance
• Polymorphism, Single Nucleotide
• Risk Factors

Identifiers and source

Literature Corpus work

b6dcfe45-4f1b-5cbb-80b5-bd210f8b13d3

DOI

10.1101/2024.07.23.24310854