Article

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cord

2023-04-24

Abstract excerpt

Transforming growth factor-β (TGF-β) signaling is critical for microglial maturation during development and the maintenance of microglial homeostasis in adulthood. It remains unclear whether regional susceptibilities to the loss of TGF-β signaling in microglia also exist, and the contributing factors have yet to be identified. We find that deletion of Tgfbr2 on microglia leads to microglial activation and demyeli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9465ae54-9157-5a66-8c40-3b047c5aaee2
DOI: 10.1101/2023.04.24.538074

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cordDOI 10.1101/2023.04.24.538074Read

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brainSemantic proximity Read

Radial glia promote microglial development through integrin α <sub>V</sub> β <sub>8</sub> -TGFβ1 signalingSemantic proximity Read

Single nucleus RNA-sequencing study revealed expansion of Gpnmb+ microglia in aged mouse spinal cordSemantic proximity Read

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read

Youth-associated protein TIMP2 alters microglial state and function in the context of agingSemantic proximity Read

The meningeal transcriptional response to traumatic brain injury and agingSemantic proximity Read

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read

The meningeal transcriptional response to traumatic brain injury and agingSemantic proximity Read

A Unique TGFB1-Driven Genomic Program Links Astrocytosis, Low-Grade Inflammation and Partial Demyelination in Periplaques of Spinal Cords from Progressive Multiple Sclerosis PatientsSemantic proximity Read

Single-cell RNA sequencing reveals time- and sex-specific responses of spinal cord microglia to peripheral nerve injury and links ApoE to neuropathic painSemantic proximity Read

Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolutionSemantic proximity Read

Regional and sub-regional microglial heterogeneity in the steady-state mouse brain and retinaSemantic proximity Read