Article

Microglia-derived TGF-β1 ligand maintains microglia homeostasis via autocrine mechanism and is critical for normal cognitive function in adult mouse brain

2023-07-07

Abstract excerpt

While TGF-β signaling is essential for microglial function, the cellular source of TGF-β ligand and its spatial regulation remains unclear in the adult CNS. Our data support that microglia, not astrocytes or neurons, are the primary producers of TGF-β1 ligands needed for microglial homeostasis. Microglia (MG)- Tgfb1 inducible knockout (iKO) leads to the activation of microglia featuring a dyshomeostatic transcrip...

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Literature Corpus work: c0f04169-7682-5789-8fed-39032d0fc156
DOI: 10.1101/2023.07.05.547814

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