Article

Microtubule end stabilisation by cooperative oligomers of Ska and Ndc80 complexes

2025-07-06

Abstract excerpt

<h4>ABSTRACT</h4> During mitosis, properly aligned chromosomes stabilise microtubule ends with the help of kinetochores to ensure timely segregation of chromosomes. Microtubule-binding components of the human outer kinetochore, such as Ndc80 and Ska complexes, are present in multiple copies and together bind several microtubule ends, creating a highly multivalent binding interface. Whereas Ndc80:Ndc80 and Ndc80:m...

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Literature Corpus work: f0674347-5e1b-58e3-8168-e40b4a454105
DOI: 10.1101/2025.07.06.663352

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