Article

Animal-free recombinant nanobody rescues HCN4 channel deficit in sinus node dysfunction

2025-03-23

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) control cardiac and neuronal firing and their dysfunction leads to cardiac arrythmias (HCN4), epilepsy (HCN1) and chronic pain (HCN2). Prompted by the urgent need for HCN subtype-specific treatments, we screened a recombinant nanobody library in search of HCN4-specific binders. Here we show that nanobody 5 (NB5) binds to the extracellular side o...

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Literature Corpus work: afc20767-d3db-5f66-8f88-fb6d78f34b3b
DOI: 10.1101/2025.03.20.644287

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