Article

Gene Therapy with the N-terminal Fragment of Na <sub>v</sub> 1.5 for Cardiac Channelopathies: A Novel Transcomplementation Mechanism Potentiating the Cardiac Sodium Current

2024-11-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Cardiac channelopathies, caused by mutations in ion-channel genes, can lead to sudden cardiac death (SCD) via ventricular arrhythmias. Brugada syndrome (BrS) is a rare inherited channelopathy characterized by a unique ECG pattern and a high incidence of ventricular fibrillation leading to SCD in the absence of structural heart defects. The main gene responsible for 20-25% o...

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Literature Corpus work: 4e7a1652-ffbd-5919-901e-4545c9c4013a
DOI: 10.1101/2024.10.30.621028

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