Differential contribution of HCN1 and HCN4 to the synchronisation of sinoatrial pacemaker cells

Abstract excerpt

The heart's ability to beat with high precision, with a regular and steady rhythm relies on the synchronised activity of pacemaker cells in the sinoatrial node (SAN), which communicate with one another through gap junctions. This process ensures that electrical impulses are organised and reach a critical mass to ignite the electrical activity of the surrounding atrial tissue and trigger the regular heartbeat. Hypo...

Topics

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• Sick Sinus Syndrome
• Action Potentials
• Biological Clocks
• Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
• Ion Channel Gating
• Models, Cardiovascular
• Myocytes, Cardiac
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

939a51e6-c79e-51b6-a12a-6c5bd0346e41

DOI

10.64898/2025.12.16.694405