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Article

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

3 Aug 1999

Abstract excerpt

Rhythmic activity of neurons and heart cells is endowed by pacemaker channels that are activated by hyperpolarization and directly regulated by cyclic nucleotides (termed HCN channels). These channels constitute a multigene family, and it is assumed that the properties of each member are adjusted to fit its particular function in the cell in which it resides. Here we report the molecular and functional...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 10430953
DOI: 10.1073/pnas.96.16.9391

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