Article

Subunit-specific conductance of single HCN pacemaker channels at femtosiemens resolution

2024-09-03

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate rhythmic electrical activity in neuronal and cardiac pacemaker cells 1 . The channels are activated by hyperpolarisation of the membrane voltage and additionally tuned by the second messenger cAMP at sympathetic stimulation. There are four mammalian isoforms, HCN1-4 2–4 . The single-channel conductance, γ , of HCN...

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Literature Corpus work: 52791498-9e82-5d55-94c3-78d16b47b71e
DOI: 10.1101/2024.09.02.610748

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