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Article

A rare HCN4 variant combined with sick sinus syndrome, left ventricular noncompaction, and complex congenital heart disease.

Channels (Austin, Tex.) - 1 Dec 2025

Zhang Fengxiao, Zhao Ning, Wang Lin, Peng Hua, Jiang Ying, Cheng Min, Zhu Feng

Abstract excerpt

The hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4) gene has been reported to regulate the spontaneous depolarization of sinoatrial node cells. A novel HCN4 mutation (c.2036 G>A) may lead to sick sinus syndrome. The green fluorescent protein (GFP) and either the wild-type (WT) or C679Y mutant (mut) were co-transfected into HEK293 cells to investigate the impact of the mutation on...

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Identifiers

PMID: 40613349
DOI: 10.1080/19336950.2025.2517851
PMCID: PMC12233691

Genes

HCN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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