Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis.

doi:10.1016/j.cell.2026.07.008

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Article

Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis.

Cell - 17 Sept 2026

Petrescu Joana, Gouveia Roque Cláudio, Jackson Christopher A, Daly Aidan C, Butti Zoé, Kang Kristy, Casel Obadele, Leung Matthew, Reilly Luke, Eschbach Jacqueline, Gebremedhin Brhan, McDade Karina, Gregory Jenna M, Bonneau Richard, Smith Colin, Phatnani Hemali

Abstract excerpt

Cognitive manifestations, including impairments in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the underlying mechanisms remain unclear. We mapped prefrontal cortex regions from ALS patients by integrating spatial and single-nucleus transcriptomics in a cognitively stratified patient cohort. We uncover that cognitive impairment in ALS is associated with distinct patterns...

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Topics

Amyotrophic Lateral Sclerosis
Humans
Executive Function
Phenotype
Language

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Prefrontal Cortex

Male

Neurons

Middle Aged

Cognitive Dysfunction

Aged

Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 42551425
DOI: 10.1016/j.cell.2026.07.008
PMCID: PMC13480947

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