Article

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohort

2026-08-30

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive dysfunction and loss of upper and lower motor neurons. Although motor neuron degeneration ultimately drives paralysis, neuronal dysfunction may precede cell death by a prolonged interval, suggesting that vulnerable neurons engage stress-adaptive programs that permit survival despite impaired function. Cellular sen...

Identifiers and source

Literature Corpus work: aeb67763-609a-5db3-839a-54f6c07ec06f
DOI: 10.64898/2026.08.28.747944

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohortDOI 10.64898/2026.08.28.747944Read

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvementSemantic proximity Read

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosisSemantic proximity Read

Glial metabolic states in human sporadic amyotrophic lateral sclerosis uncovered by spatial single-cell proteomics.Semantic proximity Read

A region-delineated snRNA-seq atlas of mouse spinal cord across lifespan resolves the interaction of normative aging programs with SOD1-G93A ALSSemantic proximity Read

Chronological and Biological Aging in Amyotrophic Lateral Sclerosis and the Potential of Senolytic TherapiesSemantic proximity Read

Tau protein aggregation induces cellular senescence in the brainSemantic proximity Read

Molecular hallmarks of ageing in amyotrophic lateral sclerosisSemantic proximity Read

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated GliaSemantic proximity Read

Tau protein aggregation is associated with cellular senescence in the brainSemantic proximity Read

Emerging mechanisms of molecular pathology in ALSSemantic proximity Read

Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic targetSemantic proximity Read

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.Semantic proximity Read