Article

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis

2025-02-27

Abstract excerpt

<h4>ABSTRACT</h4> Cognitive manifestations, including impairment in language and executive functions, are seen in amyotrophic lateral sclerosis (ALS), but the mechanisms that underlie these deficits remain unclear. To address this, we mapped prefrontal cortex regions from ALS patients by integrating spatial and single-nucleus transcriptomics in a cognitively stratified patient cohort. We uncover that cognitive im...

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Literature Corpus work: d65caf5b-37af-53d5-9a57-729f646c3c27
DOI: 10.1101/2025.02.26.640433

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