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Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling

2025-10-20

Abstract excerpt

<h4>SUMMARY</h4> The Calcitonin gene-related peptide (CGRP) receptor has gained attention in Alzheimer’s Disease (AD) research due to its involvement in regulating neuroinflammation. However, its role and mechanism in AD pathology remain unclear. Here, we demonstrate that CALCRL, a core component of the CGRP receptor, is upregulated in the hippocampus of AD dementia patients and 5×FAD mice. Knockout of the CGRP r...

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Literature Corpus work
af698515-5688-5e71-9070-8e032ef2ef06
DOI
10.1101/2025.10.17.683079
Open publication

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Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signalingDOI 10.1101/2025.10.17.683079
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