Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Hwang Sung Hee, Shin Eun-Joo, Shin Tae-Joon, Lee Byung-Hwan, Choi Sun-Hye, Kang Jiyeon, Kim Hyeon-Joong, Kwon Seung-Hwan, Jang Choon-Gon, Lee Jun-Ho, Kim Hyoung-Chun, Nah Seung-Yeol

Abstract excerpt

Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular mechanisms of how ginseng exerts its effects. Recently, we isolated a novel lysophosphatidic acid (LPA) receptor-activating ligand from ginseng, gintonin. AD is caused by amyloid-β protein (Aβ) accumulation. Aβ is derived from amyloid-β protein precursors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Egtazic Acid
Share to Indans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoxazoles

Share to Memory Disorders

Share to Metalloproteases

Share to Phytotherapy

Share to Propionates

Source

Identifiers

PMID: 22543851
DOI: 10.3233/JAD-2012-120439

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.PMID 22543851Read ↗

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.Semantic proximity Read ↗

Gastrodin ameliorates synaptic impairment, reestablishes mitochondrial membrane potential and reduces oxidative stress in N2a/APP cells through ERK1/2 and GSK-3β pathwaysSemantic proximity Read ↗

Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signalingSemantic proximity Read ↗

(-)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer's Disease PSEN1 E280A.Semantic proximity Read ↗

A screen of plant-based natural products revealed that quercetin prevents amyloid-β uptake in astrocytes as well as resulting astrogliosis and synaptic dysfunctionSemantic proximity Read ↗

The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylationSemantic proximity Read ↗

Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α.Semantic proximity Read ↗

Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.Semantic proximity Read ↗

PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease.Semantic proximity Read ↗

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons.Semantic proximity Read ↗

Ginkgo biloba Extract EGb 761 and Its Specific Components Elicit Protective Protein Clearance Through the Autophagy-Lysosomal Pathway in Tau-Transgenic Mice and Cultured Neurons.Semantic proximity Read ↗

Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.