Article

Inhibition of CGRP receptor ameliorates AD pathology by reprogramming lipid metabolism through HDAC11/LXRβ/ABCA1 signaling

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>The Calcitonin gene-related peptide (CGRP) receptor has gained attention in Alzheimer’s Disease (AD) research due to its involvement in regulating neuroinflammation, but its role and mechanism in AD pathology remain unclear. Here, we demonstrate that CALCRL, a core component of the CGRP receptor, is upregulated in the hippocampus of AD dementia patients and 5×FAD mice. Knockout of the C...

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Literature Corpus work: 0be69b8c-c5aa-5380-acb4-729db4db8dec
DOI: 10.21203/rs.3.rs-9358637/v1

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